The safest Isaac backup begins by naming the active DLC generation. Do not restore a Repentance-era file into a Rebirth-only directory just because both belong to the same game family.
For this PC reference, the documented storage is Windows: %USERPROFILE%DocumentsMy GamesBinding of Isaac Rebirth (DLC can use a title-specific sibling folder such as Binding of Isaac Repentance). The known file or folder pattern is persistentgamedata/options and Steam-cloud mirror records depending on DLC/version. Rebirth-family PC data changes directory naming across major DLC releases. Treat the exact installed expansion as part of save identity and preserve both persistent game data and any cloud mirror involved.
Backup guidance: Close The Binding of Isaac: Rebirth, let the launcher finish any synchronization, then copy the complete documented save directory to a dated folder outside the live path. Preserve companion files rather than selecting only the newest-looking record. Steam Cloud integration is significant and DLC versions can use different local filenames/folders. Launcher and cloud context matters because The active Steam installation determines which local profile and cloud copy can overwrite the save. Identify the storefront and account before restoring files.
Compatibility and recovery should stay conservative. Treat saves as version-, storefront-, account-, and mod-sensitive unless the game or a separately verified migration workflow proves otherwise. A similar filename or extension is not evidence that two releases are interchangeable. If the expected progress is not visible, If progress is missing after a restore, confirm the active Windows account, storefront/profile, cloud state, and exact directory first. Restore the untouched backup before experimenting with individual files or older autosaves. SaveEditor.com only labels a game-specific editor as available when a separate linked Tool has a verified operational runtime; this reference page by itself is not an editor claim.